Transplantation. Jul 27;66(2) Uricosuric effect of the angiotensin II receptor antagonist losartan in heart transplant recipients. Minghelli G(1). This agent promotes uric acid excretion via effects on the organic anion transport The AIIA losartan also produces a uricosuric effect in healthy volunteers. Uricosuric medications (drugs) are substances that increase the excretion of uric acid in the urine, thus reducing the concentration of uric acid in blood plasma. In general, this effect is achieved by action on the proximal tubule of the the uricosurics benzbromarone and losartan had no effect, suggesting these drugs act.

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Rayner and colleagues conducted an open-label, randomized, controlled, two-parallel group study [ Rayner et al. Valsartan in the treatment of hypertension. Losartan was well tolerated and no participants experienced urate nephropathy [ Shahinfar et al.

On the other hand, in hypouricemic hypertensive patients with URAT1 mutations hypertensive case no. This review explored the available literature for the urate-lowering effects of ARBs.

In conclusion, uricosric is the only ARB that has consistently demonstrated a significant reduction in serum uric acid levels, although the significance of impacting clinical outcomes remains unknown.

None of them had gout or urinary calculi, or were they under treatment with oral antidiabetic agents, nonsteroidal anti-inflammatory drugs or fibrates.

From those, eight studies met criteria [ Rayner et al. High-dose salicylate and indomethacin have both been studied for their uricosuric effects [ Shin et al.

Uricosuric – Wikipedia

Losartan induced a significant increase in Cur 4. Drugs that reduce blood uric acid are not all uricosurics; blood uric acid can be reduced by other mechanisms see other Antigout medications.


Shahinfar and colleagues conducted urjcosuric double-blind, placebo-controlled, parallel study with 63 patients to explore the safety and efficacy of losartan in individuals with thiazide-induced hyperuricemia [ Shahinfar et al.

Losartan has demonstrated renoprotective effects directly related to the degree of serum uric acid lowering; however, these endpoints were not explored in the included studies that enrolled patients with baseline hyperuricemia or a gout diagnosis [ Ito et al.

Close mobile search navigation Article navigation. We could enroll only four hypouricemic patients without hypertension and five hypouricemic patients with hypertension for this study, because renal hypouricemia itself is a rare disease with an incidence of 0.

Lodartan of losartan on renal excretion of urate in a hypouricemic hypertensive patient no.

The two treatment groups were comparable in terms of age, BMI, weight, height, baseline sitting BP, fasting plasma glucose levels, serum levels of total cholesterol, and triglycerides. A novel type of renal hypouricemia. Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction. Individuals with secondary hypertension, significant cardiac history including MI within the past year, and transient ischemic attack TIA or cerebrovascular attack CVA within the past 3 years were excluded.

While utilized for similar indications, the available ARBs differ widely in their chemical structures, which correlate to various differences in their pharmacodynamic and pharmacokinetic effects.

Uricosuric effect of losartan in patients with renal transplants.

It also resulted in lower uric acid levels. These patients were unrelated and provided written informed consent for the study. Urate transport in the kidney involves glomerular filtration, reabsorption, secretion, and losartn reabsorption. Therefore ARBs play a significant role in the treatment of hypertension and as renoprotective agents [ Michel et al. Losartan showed a slightly higher hypotensive effect than valsartan in patients newly diagnosed with gout. Gout is an arthritis classified commonly by uric acid crystallization that occurs within joints [ Choi et al.


These findings highlight a niche for the incorporation of losartan into therapeutic regimens for individuals with thiazide diuretic-induced hyperuricemia. Thus, use of these drugs is contraindicated in persons already with a high urine concentration of uric acid hyperuricosuria. There was no safety analysis conducted in this study [ Khan et al.

Urine uric acid excretion increased at hours 2, 4 and 6 on day 1. Support Center Support Center. National Center for Biotechnology InformationU.

J Hum Hypertens ; Wilcoxon’s test was used to assess the effect of losartan on hypouricemic patients.

Uricosuric effect of losartan in patients with renal transplants.

While this is occasionally exploitable to good effect see oseltamivirassessment of drug interactions is very important when using uricosuric drugs effecr the presence of other medications. There were no statistical differences in the pre- and postadministration values between the two groups. Serum uric acid and cardiovascular disease: J Pharmacol Exp Ther In a population-based study from the United Kingdom inresults showed that the prevalence of gout has increased by